The focal score is the sum of three components: Functional Impairment, Magnitude of Task, and Magnitude of Effort (see text below).

Different groups of researchers use different parameters and different scores to assess the efficacy of bronchodilators.

.....Another symptomatic assessment was the Mahler Baseline and Transitional Dyspnea Index (BDI/TDI) scores, assessed at baseline (BDI) and after 7, 13, 25, 37, and 49 weeks of treatment (Days 50, 92, 176, 270, and 344, respectively). These scores include three components: Functional Impairment, Magnitude of Task, and Magnitude of Effort. The Focal Score is the
sum of the three components. At baseline, the two treatment groups were comparable for each component and for the focal score [U99-3169.pdf/p125]. Tiotropium was statistically superior to placebo for all three components and for the focal score, except for Day 260 for Functional Impairment. The effect size that would represent a clinically meaningful benefit has not been
firmly established in the literature. The Applicant states that the developer of the instrument has expressed the opinion that a value of 1 in the focal score would be clinically meaningful. The difference in focal score between tiotropium and placebo was >1 on the final test day only......

http://www.fda.gov/ohrms/dockets/ac/02/briefing/3890B1_05_Cl...

Zie voor effectparameters en scores in dit artikel: Ketenzorg COPD,
onder rubriek 14.6

Dyspneu:
• CRQ/Qol-RIQ: de dyspneudimensies (zie onder);
• ‘Baseline/transient dyspneu index’ (BDI/TDI) (Nederlandse versie in Bronchus-trial);98,99
• MRC-dyspneuscore: een vrij grove maat, meer geschikt voor classificatie;59
• Borg-score bij inspanning: geeft ook inzicht, maar meet een specifieke dyspneudimensie
terwijl de score mede afhangt van de gehaalde inspanning, zodat de vergelijking op gelijk inspanningsniveau dient plaats te vinden.

http://www.astmafonds.nl/ketenkwaliteit/richtlijn ketenzorg ...



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Note added at 15 hrs (2012-08-07 06:22:33 GMT)
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My suggestion is to leave it untranslated.

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Note added at 21 hrs (2012-08-07 13:04:35 GMT)
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Misschien kan je het zo zeggen: focal score (de som van 3 componenten:functionele beperking, taakomvang en mate van inspanning)

http://www.cvz.nl/binaries/live/cvzinternet/hst_content/nl/d...

De Mahler TDI (Transitional Dyspnoe Index TDI) meet specifiek de invloed van dyspnoe op het dagelijks functioneren. In Mahler TDI worden de beperkingen in het dagelijks functioneren, bij welk type lichamelijke inspanning dyspnoe optreedt en bij welke intensiteit van inspanning gemeten. De ‘focal’ score is de som van deze 3 parameters; een verandering ≥1 wordt i.h.a. klinisch relevant beschouwd.