colony outgrowth assay (study)

09:33 Jul 15, 2020
This question was closed without grading. Reason: Other

English to Russian translations [PRO]
Law/Patents - Medical: Pharmaceuticals / Анализ эффективности комбинированной противоопухолевой терапии
English term or phrase: colony outgrowth assay (study)
In colony outgrowth studies in GIST cells, Compound A exhibited superior synergy in combination with a MEK inhibitor compared to imatinib in combination with a MEK inhibitor.

Furthermore, the combination therapy disclosed herein appeared to eradicate GIST tumor cells to the limit of detection, with no tumor cell colony outgrowth after removal of combination therapy including drug-free recovery periods of up to 21 days.

Studies were performed which demonstrate that combination treatment with Compound A and trametinib prevents colony outgrowth in GIST-T1 (57bp exon 11 deletion) imatinib sensitive cells, GIST-T1/D816E imatinib resistant cells and GIST-T1/T670I imatinib resistant cells.


Анализ (исследование) разрастающихся колоний?

В отечественной литературе встречается аналогичный термин применительно к эндотелиальным клеткам.
разрастающиеся эндотелиальные клетки - (outgrowth endothelial cells, OEC).
http://www.tsitologiya.incras.ru/60_4/matveeva.pdf
Wolfskin
Local time: 06:44


Summary of answers provided
3анализ роста колонии
Natalia Vlasova


  

Answers


10 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
анализ роста колонии


Explanation:
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    https://cyberleninka.ru/article/n/analiz-matematicheskoy-modeli-rosta-kolonii-biologicheskih-obektov
Natalia Vlasova
Russian Federation
Local time: 07:44
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 63
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