Dec 13, 2021 12:42
2 yrs ago
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English term

Qualified Absolute AC50 value

English to Russian Law/Patents Medical: Pharmaceuticals Получение лекарственных препаратов-ингибиторов KARS
"NC1 control based normalization was used for data analysis in Helios, which incorporates the DMSO neutral control (NC) and MG132 active control (AC) for generating dose response curves that are then used to calculate the Absolute Qualified AC50 calls for each compound and cell line.
NC1 normalization calculation model:
+/- is set by the inhibition type parameter setting where NC and AC are averages (mean or median) over the corresponding NC and AC well values.

The Qualified Absolute AC50 values for Compound 36 and Compound 40 are listed in the table below and are represented as the average activity in both the PrestoBlue and Cell Titer Glo assay readouts.
Absolute Qualified AC50 values listed below are a representation of each compounds' average activity in both the PrestoBlue and Cell Titer Glo assay readouts."

Термин из протокола анализа клеточной пролиферации для оценки активности исследуемого соединения. Термин, видимо, авторский. Причем AC50, скорее всего относится не к active control, а к "concentrations causing fifty percent activity (AC50)". Такой нашел в публикации по ссылке ниже:

https://www.nature.com/articles/s41540-020-00166-2

Спасибо!

Discussion

Wolfskin (asker) Dec 13, 2021:
Уточненное абсолютное значение AC50? Или же опытное абсолютное значение AC50?

Proposed translations

4 hrs
Selected

отвечающая требования концентрация достижения 50%-й активности



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Note added at 4 hrs (2021-12-13 16:56:20 GMT)
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опечатка - требованиям
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