English to Serbian Medical Medical (general)

NUT carcinoma, formerly known as NUT-midline carcinoma (NMC), is a rare and very aggressive form of cancer that can form anywhere in the body, but often forms along the midline structures (head, neck, or lungs). It occurs all over the world in both adults and children of both sexes.
NUT carcinoma is an undifferentiated or poorly differentiated squamous cell carcinoma, meaning the cancer begins in squamous cells in the body. Squamous cells normally line hollow organs in the body, such as the respiratory tract. It is defined by a specific genetic mutation known as a fusion oncogene. A fusion gene is made by joining parts of two different genes together. In the case of NUT carcinoma, the NUT gene is joined to another gene (usually BRD4, but in some cases BRD3, NSD3, or other genes). This gene fusion causes the abnormal uncontrolled squamous cell growth.